A spokesperson for the state-run Pakistan International Airlines (PIA) Abdul Sattar told the newspaper Dawn that the flight was carrying 90 passengers and 8 crew members and had been due to land in Karachi at 14:45 local time (09:45 GMT).
The newspaper said a rescue operation was underway and emergency workers had arrived at the scene. There were no immediate reports on the number of casualties.
Pictures and videos posted on social media show smoke rising from the crash site in Karachi.
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